Moisture is the biggest enemy of any sensitive product, like metal or electronic items. So, to ensure the products safety of the products, it is important to check the atmospheric conditions of the place where the product has to be stored. This is not only the best rather the cheapest way to know about the atmospheric humidity. Moisture is not the only time when the product has moisture danger. Even while transporting, any item can easily come in contact with atmospheric moisture, and many lose their originality. There are various products in the market which help to absorb moisture from the environment. But how may someone know which desiccant to use in different humidity situations? Check the atmospheric humidity with humidity indicator cards and then use the appropriate desiccant.
Now, the question arises what are the indicator cards made up of, which makes them so efficient that they can analyze the amount of humidity in the atmosphere. The cards have a layer of cobalt chloride solution mixed carefully to change their colour from blue to various shades of magenta, red to pink. These cards are not made to indicate the exact amount of moisture in the environment. Still, they can efficiently tell the range of maximum possibility of humidity present in the container. For example, if a card indicates 10%- 60% of moisture if the dots' colours are deep blue, then you can be sure that the humidity is below 10%. It is very important for many products that the humidity level stays below 40% because the basic corrosion or rusting activity will never happen in this range.
These humidity indicating cards are used for various purposes like storing your wedding dress heirloom, electronic items, computer products, old photographs, personal items and many more. Apart from this, it is also used to store optical instruments, bilk packaging and preserve sensitive components. It is also used in bulk to pack dry products like various semiconductors and electronic items. The advantage of using this humidity indicator card is that it is very easy and a fast moisture monitoring tool. If required, it can also be customized. There are two types of humidity indicating cards cobalt-free cards and cobalt cards. Both people mostly use cobalt cards because of their moisture indicating technique is more appropriate and accurate.
Whether pharmaceutical, electronic, or food, any product can be badly affected by moisture. When any of the products is preserved or stored, the chances of being affected by moisture increase. With the help of desiccant canisters, the life of the products can be increased as the canisters help prevent packaging moisture. Desiccant canisters are mostly used in the pharmaceutical industry to package bottles and tablets. It has a very high capacity and speed for adsorbing moisture, and just because of this feature, they are the best option to be used with any food items or medicine. Apart from the silica gel, various canisters use various materials, like activated carbon and molecular sieves. These desiccants can control moisture and help control rust, mold, and any other type of deterioration activities that occur due to moisture.
Among all, silica gel canisters are considered the best option to be used, especially in the case of the pharmaceutical industry. It increases the lifespan of the product and is also the reason to retain the freshness and effectiveness of the item by keeping the packaging environment dry. The best thing about the desiccant canisters is that they are nontoxic, and thus this makes them flexible even to use with the food items. Whenever you choose a company for buying a desiccant canister, it is necessary to check if the company follows FDA standards in manufacturing the product. If it has successfully undergone all the FDA standards, it can be used in close contact with any food and pharmaceutical item. There are unique shapes and sizes of desiccating canisters available on the market. It is available in sizes starting from 0.5 to 3 grams.
With the help of these canisters, products can be given a controlled and packed environment that requires moisture controlled and odour free environment. The packaging platform can be customized according to the requirement and needs of the customers. When silica gel or desiccant clay is used in canisters, it is used for absorbing moisture. In contrast, Molecular sieves and activated carbon are used to adsorb gaseous activities like odour control. These desiccants are small and cylindrical can containers stuffed with highly active desiccant agents. The special design of these canisters allows them to be inserted and used continuously with packed pharmaceutical products. There are several sizes and variants available on the market for these canisters from which you can choose according to your requirements.
A somewhat similar concept to the desiccant canister, which is also available in various products and sizes and is provided by Sorbead India. There are various benefits of using these desiccant canisters or capsules that is it has a very effective adsorption rate, which helps in providing a moisture and odour free environment to the product. Sorbead India provides canisters at very cheap prices with flawless quality.
What is the MVTR Testing?
MVTR is the acronym used for Moisture Vapor Transmission Rate. This is the rate used to measure the passage or permeance of water vapor through a substance. Moisture control remains a major topic when it comes to packaging in the pharmaceutical industry. The extent of damage moisture interference can cause is adverse and irreversible.
Every substance permeates water vapor. But if how much is the question, then it can be only depicted by the MVTR value. Pharmaceutical industries have to make sure that their blister packaging is well built to protect the medicines from moisture content. To test that they will verify if the MVTR value of their packaging meets the USP standards or not.
Desiccant tablets are used to measure the MVTR of these pharmaceutical packages.
What are desiccant tablets?
These are desiccants in the form of small tablets. Desiccant tablets are used in controlling moisture content from pharmaceutical tablets and capsules. The desiccants are best suitable for blister packaging that will prevent moisture from invading inside the tablet. Being available in tiny shapes and sizes, they fit in easily in these packages even during the manufacturing process. Desiccant tablets are also used in nutraceuticals, medical diagnostics, military, and electronics.
Advantage of desiccant tablets:
- High performance
- Requires no additional space
- Act as an individual adsorption device
Use of desiccant tablets for MVTR testing
Desiccant tablets being compact are extremely useful in understanding the permeance of these pharmaceutical packaging. These high-quality desiccant tablets are placed individually or as a whole over inside the blister packaging spaces. Later on, after a given period, these desiccant tablets are taken to test and verify the moisture vapor transmission rate that is allowed as per the given standard for the particular packaging. In this way, pharmaceutical packaging companies can make sure their packaging meet all the standard and keep the products safe from any kind of moisture interventions.
Sorbead India is one of the prime desiccant capsules and tablets manufacturers and suppliers who serve their clients across the world with the best quality products. Being the finest desiccant supplier in the industry, Sorbead India has rendered their products in food, electronics, agriculture, military, aerospace, automobile parts, nutraceuticals, and pharmaceutical industries.
Sorbead India is well known for its high-quality absorbers and desiccants. Its Desiccant pillow packs consist of a wide variety of sizes, configurations, and substrates. These can be used to absorb moisture vapor, odor and gas according to your desire. We also provide custom blends that can be used as a multifunction package. The multi-function packs absorb two or more unwanted substances from the container. They are available in a wide range of different sizes of ¼, ½, ¾, 1, 1 ½, 2, 3, 4, 5, 7, 10, 12 or 14 grams. The different materials used for desiccant material silica gel, indicating silica gel, clay, molecular sieve and carbon packed in Tyvek, non-woven or clear view desiccant Packs.
They are used to absorb moisture from 1 gallon can or 10-gallon containers. Desiccant pillow packs are used in pharmaceutical, electronics, diagnostic kits, foods, clothing, powders, vitamins, consumer products, and parts industries to extend the shelf life of the products by absorbing all the moisture and keeping a balance in humidity. Our pillow packs meet FDA and USDA standards and are used in a variety of package applications. These desiccant pouches are also used for the dehumidifier process using a molecular sieve and silica gel packets.
We are prominent manufacturers, suppliers, and exporters of superior quality desiccant pillow packs. These pillow packs are ideal for use in both industries and households for protection from moisture. Desiccant Pillow Pack supplied as per the international standards USFDA ensures high durability and good quality. They have high absorbent capacity for humidity and easily protect containers from moisture damage while goods are in transit. They are also environment-friendly, non-corrosive, and non-toxic and can be disposed of off like any normal waste when removed from containers and boxes after full use.
Desiccants protect your pharmaceuticals by reducing air humidity. Thus, a barrier layer is needed to limit the air exchange. Desiccants come in various forms and have found its important place in the packaging of various pharmaceuticals.
Before selecting the type of desiccant, calculating the correct amount of desiccant is important for maintaining the efficacy of the product and it depends on the following parameters:
- Identifying the type of container. It differs for flexible (eg: foil or polybag) and rigid type (eg: drum or pail)
- Calculating the surface area of the container walls in ft 2 or in 2 for flexible; or the volume of the container in gal., ft3 or in3 for rigid.
- Adsorption rate and adsorption capacity of the desiccants being used.
- A number of units required also differs for flexible containers and rigid containers.
Types of Pharmaceutical Desiccants:
It contains silica gel made from amorphous sodium silicate that is highly absorptive in nature or composition. It absorbs 40% of its own weight and is highly absorbing material unlike others in the market. It is hard, translucent material with an extremely high capacity for moisture at temperatures below 75? F and humidity levels above 40 percent. It is characterized by stable properties, non-toxicity, excellent moisture absorption performance and does not affect any products it comes in contact with. It is especially suitable for the moisture-proof packaging in the pharmaceuticals.
Activated Carbon Sachet /Packet
Activated carbon used in controlling objectionable odors and gases through the process of adsorption. Activated carbon has been used extensively for many years as an adsorbent of odors and toxic gasses and it performs unmatchable functions when it comes to adsorption of odours.
Molecular Sieve Sachet /Packet
Molecular sieve is a very aggressive desiccant that can be used to quickly absorb moisture and odor. Molecular sieves are alumino silicates, a crystalline porous solid with a three-dimensional network with different pore sizes (3-5 Å). They have to be activated prior use and also can be regenerated at higher temperatures (180 oC - 260 oC) .It comes in the form of beads which has specific pore sizes.
Clay Desiccant Sachet /Packet
Montmorillonite clay is a naturally occurring adsorbent created by the controlled drying of magnesium aluminum silicate. It is a free-flowing granular material with high moisture adsorbing ability from 20 to 80 percent relative humidity under normal packaging and storage conditions.
An important factor that adds to the efficiency of any desiccant is the cover stock, which means material used for its packaging. The cover stock must allow the desiccant to perform its functions without causing any harm to the product. The cover stock allows the desiccant to maintain an acceptable adsorption rate. One common cover stock used widely is Tyvek, a spunbonded, high-density, polyethylene.
Hence, one should always be mindful of all the characteristics of the desiccants and material used in its packaging as well as the packaging of pharmaceuticals. All these parameters are specific to the desiccants in question and therefore are important for the consideration in order to obtain the desired results.
Maintaining and preserving the drug presentation, integrity and performance should be a manufacturer’s highest priority. Moisture management plays a critical role in any pharmaceutical process. In this article, we will analyze the significance of moisture content while packaging moisture-sensitive drugs.
Any exposure of moisture into the pharmaceutical products can subsequently affect the stability of the product. It can influence the chemical stability, crystal structure, powder flow, compaction lubricity, dissolution rate, and lead to the growth of microorganisms as well. Packaging scientists have to be mindful of their product quality right from the manufacturing till packaging. And not just it, they should also consider the fact that the moisture uptake of a product varies considerably during its lifetime, i.e. bulk packing process, storage, primary packing process, storage in consumer container to regular usage by the consumer.
The key role of moisture-sensitive packaging in the pharmaceutical industry is to limit exposure to moisture. Maintaining a low relative humidity level for better protection of humidity-sensitive drugs is crucial. Reports suggest that almost 65% of moisture content in the drugs is caused during the packaging process. Knowing the Equilibrium relative humidity or ERH of a pharmaceutical formulation or product is always beneficial in controlling the packing environment. ERH is the percentage relative humidity (%RH) at which equilibrium is achieved. By ERH value, one can predict if the material is likely to absorb or lose moisture at a given %RH.
The use of desiccants is a great option for humidity management in moisture sensitive packaging of drugs. Silica Gel Pouches, Molecular Sieve Pouches, Clay Desiccant sachet, and Activated Carbon Sachet are some of the commonly used desiccants in the pharmaceutical industry. To choose the right desiccant, it is important to know how much water vapor can be absorbed by the desiccant at various relative humidity.